Error with Sophos Patch Agent

I am trying to install Sophos endpoint on this one machine, all others endpoints have installed fine, every thing seems to go OK but on installing the Patch Agent the updater reports "cannot connect to server". But all the other packages installed fine with the same permissions fine. I've double checked permissions for the Updater folder, I've checked the user and password and also tried clearing the Sophos cache.

Below is an extract from the Auto Update log, from where I think the problem is.

Trace(2014-Aug-26 13:25:44): CIDUpdateLocation::SyncProduct - Updating Product: Sophos Patch Agent
Trace(2014-Aug-26 13:25:44): CIDUpdate(SyncProduct.Start): Sophos Patch Agent, \\ftp\SophosUpdate\CIDs\S000\SAVSCFXPTrace(2014-Aug-26 13:25:44): CIDUpdateLocation::Sync - Updating from local CID: \\ftp\SophosUpdate\CIDs\S000\SAVSCFXP\spa64
Trace(2014-Aug-26 13:25:44): CIDSync(CidSyncMessage):
Trace(2014-Aug-26 13:25:44): CIDSync(CidSyncMessage): Setup.dll
Trace(2014-Aug-26 13:25:44): CIDSyncCallback, SynchronisationTerminated - Code = -2147220477
Trace(2014-Aug-26 13:25:44): CIDSyncCallback, SynchronisationTerminated - MapFile = C:\ProgramData\Sophos\AutoUpdate\cache\spa64.map
Trace(2014-Aug-26 13:25:44): CIDUpdateLocation::SyncProduct: Failed to update product (Sophos Patch Agent) from "\\ftp\SophosUpdate\CIDs\S000\SAVSCFXP\", Error is :SDCOM_E_VFS_OPENFAILED (VFS could not open a file for reading:)
Trace(2014-Aug-26 13:25:44): CIDUpdate(CIDDownloadFailed): Sophos Patch Agent, \\ftp\SophosUpdate\CIDs\S000\SAVSCFXPTrace(2014-Aug-26 13:25:45): ALUpdate(DownloadEnded): 

Any help would be greatly appreciated, thanks.