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Refusing MAIL_FROM

The same ISP that we were having trouble with yesterday is now rejecting messages *to* our domain.  Their users are getting the following message:

 <>
command was <> does not help fight
spam, disregards ... User unknown https://community.sophos.com/products/unified-threat-management/astaroorg/f/51/t/20929

What could I have done to block this?   


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