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SMTP Proxy and Anti-Spam on 4.001

Is there any way to get the SMTP proxy to check with the Internal SMTP host to see if an address exist before accepting a message.  Spammers are sending mail to multiple names at the domain and the proxy queues them up and we have to go through the quarantine area to clean them up.  Any ideas how to get the proxy to talk to the SMTP host before it accepts a message?  


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