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Several smarthosts?

As M$ Exchange 2K7 isnt able to smtp to several different smarthosts depending on the sender's domain I was hoping that good old ASG v7 - working silently and total reliable since installation a few years ago - would be able to do that job instead: Is it possible to configure SMTP the way that depending on the sender's domain a different ISP mail server is used? 
E.g. mails from john@company1.com are being transferred to mail.company1.com, mails from jane@company2.com use smtp.company2.com while both senders are using one Exchange 2K7 protected by an ASG box? How?

Thanx
Ontario


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