Hello,
in smtp routing , when you set an ipv6 host in the host list (v4/v6 or v6 only), an error occurs and no more mail can be sent to the domains listed.
error is :
2010:04:10-13:29:25 serveur exim[15277]: 2010-04-10 13:29:25 11xcZn-0001SE-3A == ***@***** R=static_route_hostlist defer (-1): lookup of host "41D0" failed in static_route_hostlist router
41D0 is part of the host ipv6 ip ( 2001:41D0:.....)
see screen capture for configuration details.