Using Edirectory Proxy Profiles with global proxy set to transparent mode.
Upgrade prevented any browser that did not have proxy settings from working.
Adding proxy settings to the browser resolved.
Thanks,
Chris
Addendum:
In looking at my config I see that the global proxy is not set to the Internal Network (as per supports instructions when using profiles). this is likely a config issue and not a bug. My test machine had proxy settings but lab was using transparent.