Skype is not working in Sophos XG210

Hi Mahadevan,

Thank you for contacting Sophos Community.

Have you tried the following KB, kindly refer to the link below. 

support.sophos.com/.../KB-000038702

You can add the following regex exception: 

^([A-Za-z0-9.-]*\.)?api\.skype\.com/
^([A-Za-z0-9.-]*\.)?pipe\.skype\.com/
^([A-Za-z0-9.-]*\.)?gateway\.messanger\.live\.com/
^([A-Za-z0-9.-]*\.)?download\.skype\.com/
^([A-Za-z0-9.-]*\.)?metrics\.skype\.com/
^([A-Za-z0-9.-]*\.)?www\.skypeassets\.com/
^([A-Za-z0-9.-]*\.)?static\.skypeassets\.com/
^([A-Za-z0-9.-]*\.)?registrar-rr\.prod\.registrar\.skype\.com/
^([A-Za-z0-9.-]*\.)?config\.edge\.skype\.com/
^([A-Za-z0-9.-]*\.)?prod\.registrar\.skype\.com/
^([A-Za-z0-9.-]*\.)?location\.live\.net/
^([A-Za-z0-9.-]*\.)?vo\.msecnd\.net/
^([A-Za-z0-9.-]*\.)?www\.auslogics\.com/
^([A-Za-z0-9.-]*\.)?wns\.windows\.com/
^([A-Za-z0-9.-]*\.)?ocsp\.msocsp\.com/
^([A-Za-z0-9.-]*\.)?vassg142\.ocsp\.omniroot\.com/
^([A-Za-z0-9.-]*\.)?amsg\.skype\.com/
^([A-Za-z0-9.-]*\.)?adc\.trouter\.io/
^([A-Za-z0-9.-]*\.)?gfx\.login\.live\.com/
^([A-Za-z0-9.-]*\.)?msagfx\.live\.com/
^([A-Za-z0-9.-]*\.)?clientconfig\.passport\.net/
^([A-Za-z0-9.-]*\.)?msagfx\.live-int\.com/
^([A-Za-z0-9.-]*\.)?auth\.gfx-int\.ms/
^([A-Za-z0-9.-]*\.)?gfx\.login\.live-int\.com/
^([A-Za-z0-9.-]*\.)?clientconfig\.passport-int\.net/
^([A-Za-z0-9.-]*\.)?auth\.gfx\.ms/
^([A-Za-z0-9.-]*\.)?login\.live\.com/

you need more than https exceptions. you need to allow the Audio Ports to the Skype IP Ranges. Follow

https://endpoints.office.com/endpoints/worldwide?clientrequestid=b10c5ed1-bad1-445f-b386-b919946339a7