awarrenhttp_access.log report many web request blocked with stauscode 500

Hi, 

I see many web requests blocked with  action="error" and statuscode=500 if I set awarrenhttp service in Debug mode. These logs are refeared  to Microsoft links like:

url="https://config.edge.skype.com/"

url="https://login.windows.net/"

url="https://odc.officeapps.live.com/"

url="https://mobile.pipe.aria.microsoft.com/"

ecc..

I don't have any compliant from the costumers about, which makes me think there are no issues, but I would like to know what those are.

Can someone help me understanding what is generating these logs and what kind of issues they can lead to. 

SFOS 17.1.3 MR-3

Thank you