had an issue on a remote pc that had sophos installed but device was deleted in sophos central (and more than 90 days). Needed to uninstall sophos but first need to remove tamper protection
we use screenconnect (connectwise control) to remote control the pcs. You should be able to use any remote control software that is installed on the pc
need to make screenconnect work in safemode
HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\SafeBoot\Network\ScreenConnect Client create name=default type=reg_sz data=service
once that is done
Open cmd prompt with administrator rights
To Start Windows 10 in Safe Mode with Networking
bcdedit /set {current} safeboot network
shutdown -r -t 1 to restart
after restart it should be safemode with networking and you can do the sophos items listed below to remove tamper protection
once done with everything. you need to get back into normal mode
Open cmd prompt with administrator rights
To Start Windows 10 in Normal Mode
bcdedit /deletevalue {current} safeboot
shutdown -r -t 1
after rebooting it should be in normal mode then you should be able to uninstall sophos now
https://support.sophos.com/support/s/article/KB-000036125?language=en_US
- Open Command Prompt.
- Type C:and press Enter.- Note: Your Boot drive may differ from C. If so, use a command such as DiskPart and list volume to show the available volumes.
 
- Type cd Windows\System32\driversand press Enter.
- Type ren SophosED.sys SophosED.sys.oldand press Enter.
- Type exitand press Enter.
- Click Continue.
- Once back in Windows, open Registry Editor.
- Back up the registry.
- Go to HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Sophos MCS Agentand set the Value data of Start to0x00000004
- Go to HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\SAVServiceand set the Value data of Start to0x00000004
- Go to HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Sophos AutoUpdate Serviceand set the Value data of Start to0x00000004
- Go to HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Sophos Endpoint Defense\TamperProtection\Servicesand under every subkey in this location set the Value data of Protected to 0.- Example:
- Go to HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Sophos Endpoint Defense\TamperProtection\Services\SAVServiceand set the Value data of Protected to 0.
 
- Go to 
 
- Example:
- Go to HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Sophos Endpoint Defense\TamperProtection\Configand set the Value data of SAVEnabled and SEDEnabled to0.
- Set the Value data of Enabled to 0in the following:- 32-bit: HKEY_LOCAL_MACHINE\SOFTWARE\Sophos\SAVService\TamperProtection
- 64-bit: HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Sophos\SAVService\TamperProtection
 
- 32-bit: 
- Restart the endpoint or server to turn off tamper protection completely.
 
				 
		