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Can't remove Mal/Iframe-F from Macintosh running 10.5.8

Please excuse me if this has been discussed before, but I seem to be unable to identify or remove the source of a Mal/Iframe-F virus that has infected by iMac that is running OS 10.5.8.

I regularly receive the same set of messages concerning an infected .mp3, .ppt, files, which appears briefly when I open the Quarantine Manager.  I am also running ClamXav which is instructed to delete all infected files (they are moved to my trashbin; all files show 0 bits in trash).  ClamXav is also identifying a large number of infected Apple Mail files and moving them to the trash bin. 

Once I have opened the Quarantine window in SOPHOS, the items listed disappear (this may be due to what ClamXav is doing).  I would like to end this virus, but would like some stepwise advice on what I should do to eradicate the source problem.  Any help would be greatly appreciated.

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