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Cleanup Failed...

I have a Macmini running OS10.6.4 with Sophos 9.0.11 and have been experiencing some very slow computer response times.  I ran a full Sophos scan and two threats were detected: Troj/BHOFr-Gen and Troj/MyDoomCn-B.  However, when I tried to clean these up, it indicated "Cleanup Failed".  I also tried to delete the files that had been indicated as being responsible and got the notice: "The operation can’’’’t be completed because backup items can’’’’t be modified."

Can someone suggest the next action I should take to eliminate these files on my Mac and my Time-machine backup?  Thanks....J

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