Newbie question: Any need to boot from CD for a "clean" scan?

I'm a brand new user of Sophos AV Mac Home. I searched the forums on "boot" and "startup" but found no info on this issue... I've always been a Mac user at home, but I used Windows machines at work 'til 2002. To properly scan a Windows machine, we had to boot it from a CD or a locked floppy so we could scan for boot sector viruses. If we booted up the Windows machine from its hard drive and ran a virus scanner, it couldn't see that malware. Is there a need to do this on a Mac? That is, if I boot my Mac normally from my hard drive and run a Sophos scan, are there certain files and/or firmware that Sophos can't scan because they are "in use" or otherwise inaccessible, and would they be scannable with a boot from CD? Thanks, Peter

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