I've just had this problem. First some basics, I'm running OSX 10.5.8 on my 2007 MacBook, and my Sophos AV updates hourly.
This afternoon as I accessed a web page, AV notified me of a threat in the cache, a threat called 'Mal/Iframe-V'. Naturally I shut that page down, then I clicked my way through the clean-up sequence. When it was done and the threat listing was removed from the Quarantine Manager, there was no pop-up window to tell me what had happened, so I looked at the log, and to my surprise I saw:
"com.sophos.intercheck: 2011-06-04 14:28:40 +0100 Threat: 'Mal/Iframe-V' detected in /[my browser's cache folder]
-- followed by --
com.sophos.intercheck: Access to the file denied "
So my question is, does this mean that AV was unable to deal with this threat? If it didn't access the file, how is it supposed to eliminate it? What else do I have to do to get rid of this?